Files must conform to the predeterminedschema in order to be. Levofloxacin fda prescribing information, side effects. In case of skin contact wash off with soap and plenty of water. Levofloxacin diffuses through the bacterial cell wall and. See what is the most important information i should know about levaquin. As with other drugs in this class, some strains of.
Please note, this oelade monograph also applies to levofloxacin hydrate cas rn 8199710. Levaquin is used to treat different types of bacterial infections. Levofloxacin hemihydrate sc211735 hazard alert code key. The information and recommendations set forth are made in good faith and believed to be accurate as of the date of preparation. Levofloxacin, hemihydrate, usp, levofloxacin, levofloxacin qacid, levofloxacin, hemihydrate, usp, levofloxacin, levofloxacin q. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial dna gyrase, halting dna replication. The cdc recommends use as an alternative therapy only if standard parenteral cephalosporin therapy is not feasible. Show this safety data sheet to the doctor in attendance. Levofloxacin is a chiral fluorinated carboxyquinolone. Levofloxacin, sold under the trade names levaquin among others, is an antibiotic. The effectiveness of levofloxacin is based on plasma concentrations achieved in humans, a surrogate endpoint reasonably likely to predict clinical benefit. Levofloxacin 5 mgml solution for infusion summary of.
Material levofloxacin tablets 250 mg, 500 mg and 750 mg manufacturer lupin limited goa 403 722 india distributor lupin pharmaceuticals, inc. Pelvic inflammatory disease unlabeled use cdc, 2010. Levofloxacin 250 mg filmcoated tablets levofloxacin 500 mg filmcoated tablets levofloxacin read all of this leaflet carefully before you start taking this medicine because it contains important. Material safety datasheet 9sections section 1 product information product identifier drytype transformer whmis classification optional product use electrical manufacturers name. Levofloxacin is a broadspectrum, thirdgeneration fluoroquinolone antibiotic and optically active lisomer of ofloxacin with antibacterial activity. Levofloxacin is a third generation fluoroquinolone antibacterial agent with a broad spectrum activity against. Levaquin and other antibacterial drugs, levaquin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. First aid measures material safety data sheet material levofloxacin. Pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in good faith, it is without warranty of any kind, expressed or implied. Highlights of prescribing information these highlights do not include all the information needed to use levaquin. Levofloxacin is indicated for inhalational anthrax postexposure to reduce the incidence or progression of disease following exposure to aerosolized bacillus anthracis. Systemic fluoroquinolones conversion to levofloxacin the medical staff pharmacy and therapeutics committee, with the support of the antimicrobial subcommittee, has approved the removal of intravenous iv and oral po ciprofloxacin and moxifloxacin from the inpatient formulary and the addition of ivpo levofloxacin. Levofloxacin is stereochemically stable in plasma and urine and does not invert metabolically to its enantiomer, dofloxacin. Mixture relevant identified uses of the substance or mixture and uses advised against intended use.
Fluoroquinolones, including levaquin, are associated with an increased risk of tendinitis and tendon rupture in all ages. Identification of the substancemixture and of the companyundertaking product name. Highlights of prescribing information these highlights do not include all the information needed to use levaquin safely and effectively. Levaquin oral solution, 25 mgml is a multiuse selfpreserving aqueous solution of levofloxacin with ph ranging from 5. Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Exposure controls personal protection protective clothing. The appearance of levaquin oral solution may range from clear yellow to clear greenishyellow. Page 3 of 10 last updated march 31, 2016 cepi helpful hints understanding and correcting msds file upload errors interpreting errors. Levaquin may cause serious side effects, including. Levofloxacin solution for infusion is only intended for slow intravenous infusion. This belongs to a group of medicines called antibiotics. Find msds sheets to access any material safety data sheet search our free msds online database. The present study was designed to investigate safety of levofloxacin 10 mgkg after repeated oral administration at 12 h interval for 14 days in broiler chicken 810 weeks old and weighing. Levofloxacin investigated as a drug, mutagen, and reproductive effector.
Levaquin levofloxacin tablets levaquin levofloxacin. Levofloxacin oel fastrac with ade affygility solutions. Levofloxacin tablets contain a medicine called levofloxacin. Uses of levofloxacin levofloxacin is a broad spectrum antibiotic of the fluoroquinolone drug class.
Investigation of ofloxacin, an older drug that is the racemic mixture, found that the l form the s enantiomer is more active. Material safety data sheet prepared according to 29 cfr 1910. Sds of levofloxacin, safety data sheets, cas 100986854. Antibacteriallevofloxacin reduced bacterial load compared with placebo by 4. Sds of sulfadimethoxine sodium salt, safety data sheets, cas. Aug 06, 2012 levofloxacin is a synthetic fluoroquinolone that is usually used to treat chronic bacterial prostatitis. Section 1 identification of the substancemixture and of. Extreme high moderate low section 1 chemical product and company identification product name levofloxacin. Levaquin oral solution contains the following inactive ingredients. Levofloxacin hemihydrate, levaquin hydrate, tavanic hydrate, quixin hydrate, iquix hydrate. Moxifloxacin is an antibiotic used in treatment of bacterial infections. Medication guide levaquin what is the most important. Levaquin, call your healthcare provider right away. Safety and efficacy of levofloxacin versus ciprofloxacin for.
Avelox moxifloxacin hydrochloride injection, for intravenous use. Levaquin levofloxacin is a fluoroquinolone florokwinolone antibiotic that fights bacteria in the body. Remove contact lenses, if present and if it is easy to do. Levaquin levofloxacin tablets levaquin levofloxacin oral solution levaquin levofloxacin injection levaquin levofloxacin in 5% dextrose injection to reduce the development of drugresistant bacteria and maintain the effectiveness of levaquin levofloxacin and other antibacterial drugs, levaquin. Page 3 of 5 7 handling and storage precautions for safe handling. Just upload files you want to join together, reorder them with draganddrop if you need and click join files.
We continually provide comprehensive safety and regulatory data on our safety data sheets promoting safe usage and handling of our products. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting dna gyrase bacterial topoisomerase ii, an enzyme required for dna replication, rna transcription, and repair of. Vonkaenel august 9, 2007 martindales merck index revision summary not applicable disclaimer. Levofloxacin tablets 8199710 250 mg, 500 mg and 750 mg. Measurement and correlation for solubility of levofloxacin in. The pharmacokinetics of levofloxacin lvfx, dr3355, the optically active component lisomer of ofloxacin, after a single oral administration of 100mg were studied in a total of 23 patients.
Use water to cool tanks, cisterns, or containers close to the heat source or fire. We investigated the safety and efficacy of levofloxacin compared with ciprofloxacin for the treatment of chronic bacterial prostatitis in chinese patients. Only select registry of toxic effects of chemical substances rtecs data is presented here. Nitrogen msds material safety data sheet for nitrogen n2 reference. The new sds required by osha are being added daily. If inhaled if breathed in, move person into fresh air. It is used to treat a number of bacterial infections including acute bacterial sinusitis, pneumonia, h. Capitals indicate lifethreatening, underlines indicate most frequent. Extreme high moderate low section 1 chemical product and company identification product name levofloxacin hemihydrate statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. Pharmaceutical product used as antibiotic agent details of the supplier of the safety data sheet 2. Material safety data sheet levofloxacin hemihydrate sc211735 hazard alert code key. Msds document numbern000 revision dated 03 sept 96 in an emergency, call chemtrec at 8004249300 us.
Sds of levofloxacin carboxylic acid, safety data sheets, cas. Dissolve usp levofloxacin rs in ndesmethyl levofloxacin. I highly recommend this to anyone who cant handle many antibiotics. Pdf evaluation of levofloxacin safety in broiler chickens. Ciprofloxacin hydrochloride safety data sheet supersedes revision. Levofloxacin undergoes limited metabolism in humans and is primarily excreted as unchanged drug in the urine. Wash eyes with plenty of clean and cool water for at least 10 minutes while pulling eyelids up, and seek medical assistance. Sigmaaldrich offers a number of levofloxacin products. It is indicated that the solubility data of levofloxacin in selected solvents increase with increasing temperature. Sandoz levofloxacin page 8 of 60 serious and sometimes fatal events, some due to hypersensitivity and some due to uncertain etiology, have rarely been reported in patients receiving therapy with quinolones, including levofloxacin. Levaquin levofloxacin tablets levaquin levofloxacin oral. Details of the supplier of the safety data sheet 2.
This sheet is provided as technical information only. Levofloxacin should be kept in a tightly closed container, protected from light. Understanding and correcting msds file upload errors. Buy levofloxacin hemihydrate cas 8199710, an antibiotic against gramnegative organisms, from santa cruz. Format this msds was prepared in accordance with directive 200158ec.
Antibiotic against bacterial respiratory tract infections. Pdf joiner allows you to merge multiple pdf documents and images into a single pdf file, free of charge. See actual entry in rtecs for complete information. The information, data, recommendations, and suggestions appearing in this material safety data sheet msds andor in. Ciprofloxacin hydrochloride investigated as a drug. This is the only antibiotics my body can take i have read all the bad things about this but let me tell you its a wonder drug for me i feel better within 24 hrs every time i take it the only side effect i get is the diarrhea but it comes afterwards. Therapy with levaquin may be initiated before results of these tests are known. This product does not contain any chemicals known to the state of california to cause cancer, birth defects, or any other reproductive harm. Use of levofloxacin levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial dna gyrase, halting dna replication. Health levofloxacin is contraindicated in persons with known hypersensitivity to levofloxacin, or other quinolone antibacterials. Levofloxacin c18h20fn3o4 cid 149096 structure, chemical names. By comparison, dermal levofloxacin concentrations in human subjects receiving 750 mg of levofloxacin averaged approximately 11. The infusion time must be at least 30 minutes for 250 mg or 60 minutes for 500 mg levofloxacin see section 4. Safety data sheet 109200 moxifloxacin hydrochloride.
Systemic fluoroquinolones conversion to levofloxacin. Levofloxacin is active against grampositive and gramnegative bacteria. Levaquin levofloxacin tablet, film coated janssen pharmaceuticals, inc. The solubility of levofloxacin in six solvents including ethanol, 1propanol, 2propanol, 1butanol, acetic acid and ethyl acetate in the temperature range of 288. The data on this material safety data sheet relate only to the specific material herein and do not relate to use in combination with any other material or process. Fluoroquinolones, including levaquin, are associated with. Levofloxacin is a broadspectrum antibiotic used in pharmacokinetic, antibiotic resistance, and resistance prevention studies. Medication student name anna greenberg medication ciprofloxacin cipro levofloxacin levaquin category class bacterial dna replication inhibitor, fluoroquinolone. Levofloxacin api manufacturers suppliers drug master. Prevent the products used to fight the fire from going into drains, sewers, or waterways. Levofloxacin is a fluoroquinolone antibiotic indicated for susceptible infections of various parts of the body including airways, eyes, eyelids, prostate, sinus, lungs, urinary tract, skin, and kidneys.
216 930 706 626 125 265 267 1127 391 1090 1490 1384 1118 610 1505 1454 491 1060 123 894 1509 584 1424 593 917 1429 874 995 1501 530 1240 1421 1253 466 288 412 1299 777 1245