The canalicular adenoma is a rare benign salivary gland tumor of the oral cavity, typically located in the buccal mucosa of the upper lip. Basal cell adenocarcinoma bcac is a rare neoplasm accounting for only 2. It was originally thought to be derived from terminal ducts batsakis, 1991, but that histogenesis is not universally accepted today. Epidemiology canalicular adenomas occur in the fourth to seventh decades of life and rarely before the age of 50 years. Basal cell adenoma of the lung identified with obstructive. The present report describes a case of an 85yearold woman who underwent an excisional biopsy of a preauricular lesion centred over the zygoma and subsequently developed an immediate iatrogenic facial palsy.
Canalicular adenoma is a newly recognized salivary gland adenoma that may be confused with malignant salivary gland tumors. Few cases of multiple foci of canalicular adenoma ca have been reported in literature. By madhavan nirmal, ramachandran c and veeravamal v. Pdf canalicular adenomas cas are uncommon benign salivary gland neoplasms of the oral cavity. Localization canalicular adenoma is a tumour of the minor salivary glands. Originally thought to be derived from terminal duct origin 1, 2, there has been controversy about origin and separation from other salivary gland neoplasms. Fna of basal cell adenoma has uniform small blue cells associated with variable amount of collagenous stroma. Rarely, this benign tumor may occur multifocally in the oral cavity. Canalicular adenoma ca is a benign epithelial salivary gland neoplasm characterized by chains of columnar epithelial cells arranged in thin anastomosing cords with a beaded pattern and preference for minor salivary glands, most probably originating from excretory duct cells. We report herein on a case of canalicular adenoma in the buccal mucosa of the upper lip assessed with a needle aspiration cytological study.
Multifocal canalicular adenoma of the minor labial. A 48 yearold female patient was admitted to our clinic, who suffered from asymptomatic right preauricular mass lesion for about 8 months. The tumor presents a unique histologic pattern composed of. Current medical research has not established a method of preventing the formation of canalicular adenoma of salivary gland regular medical screening at periodic intervals with blood tests, radiological scans, and physical examinations, for those who have already endured the tumor, are. Complete excision was performed and the histopathological analysis showed pleomorphic adenoma. Distinguishing canalicular adenoma from basal cell adenoma has little therapeutic significance,but distinction from adenoid cystic carcinoma has important prognostic and therapeutic implications. Therefore, the pathological diagnosis of bca, which was mainly composed of basal cells accompanied by luminal and myoepithelial cells in our case, was valid and feasible. How can canalicular adenoma of salivary gland be prevented. It is the third most common benign tumor of minor salivary glands, representing less. Ca was first described by mcfarland 1942 as canalicular tumor, then as monomorphic adenoma by rauch et al. The pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader if you would like more information about how to print, save, and work with pdfs, highwire press provides a helpful frequently asked questions about pdfs alternatively, you can download the pdf file directly to your computer, from where it. Canalicular adenoma ca is a benign salivary neoplasm that primarily affects minor salivary glands. They account for 1% of all salivary gland neoplasms.
It also provides a comprehensive overview of both common and rare salivary gland neoplasms. Canalicular adenoma ca is an uncommon but unique benign tumor of salivary gland origin. Ca is an uncommon benign neoplasm that can develop in minor salivary. Canalicular adenoma ca is a benign neoplasia of salivary glands, which although representing less than 1% of salivary gland tumours, is the second or third most common benign tumour of minor salivary glands 1,2. Canalicular adenoma, salivary glands of springerlink. The most common site is the upper lip, and the adenoma usually appears as a single lesion.
It is a rare entity, representing less than 1% of salivary gland tumors. This book focuses on the diagnostic approach to salivary gland neoplasia and emphasizes the need to understand downstream implications with respect to patient surveillance and treatment. Bcac involving palatal minor salivary glands are exceedingly rare, and only 10 cases have been reported in the literature. Canalicular adenoma is a relatively rare benign tumor of the salivary glands, found almost exclusively in the minor salivary glands of the upper lip. Canalicular adenoma composed of columnar epithelial cells arranged in single or double layer forming branching chords. We report a peculiar case of canalicular adenoma of the upper lip in a 57yearold woman, presenting as two distinct asymptomatic nodules diagnosed and treated. Canalicular adenomas cas are uncommon benign salivary gland neoplasms of the oral cavity. It is usually asymptomatic and slow growing, and accounts for less than 1% to 3% of all salivary neoplasms.
Histologically, trabecular type of basal cell adenoma, pleomorphic adenoma, and polymorphous. Canalicular adenoma is a rare benign salivary gland tumor of the oral cavity, typically located in the upper lip and. Canalicular adenoma of the upper lip mimicking mucocele. Their incidence peaks during the seventh decade of life. Report of a rare case ezher hamza dayisoylu,1ali alper pampu,2sevdegul mungan,3fatih taskesen4 department of oral and maxillofacial surgery, faculty of dentistry,1,2,4department of pathology, faculty of medicine,3 karadeniz technical university, trabzon, turkey. Canalicular adenoma type of benign salivary gland tumor occurs most often in minor salivary glands. The tumor was a circumscribed, large firm mass, about 5 cm in diameter, almost obstructing the nasal vestibule and characterized by slow growth. Here, we report a case of a 55yearold male patient with massive bcac of palatal minor salivary gland extending into. Given the usual small biopsies, ihc may be useful in distinguishing canad from other tumors in the differential diagnosis. Rarely, ca can involve the major salivary glands, for example the parotid gland. Originally thought to be derived from terminal duct origin 1. Canalicular adenoma affects primarily adults and presents at a mean age of approximately 60 years.
Pdf this case report describes a rare case of canalicular adenoma arising in the upper lip of a. Submucosal masses of the right upper lip otolaryngology. Bilateral canalicular adenoma of the parotid gland. Introduction canalicular adenoma ca is a benign salivary neoplasm that primarily affects minor salivary glands 1. Previously, along with basal cell adenoma, ca was classified as a monomorphic adenoma. Basal cell adenoma canalicular adenoma ductal papilloma monomorphic adenoma myoepithelioma oncocytoma papillary cystadenoma lymphomatosum. Canalicular adenoma ca is an uncommon benign salivary gland neoplasm. Canalicular adenoma is a rare benign salivary gland tumor that occurs almost exclusively in the upper lip. We report a case of canalicular adenoma in the upper labial mucosa of a male patient, highlighting the clinical and histopathological differential peculiarities compared to other lesions of similar location. Monomorphic adenoma canalicular type monomorphic adenoma canalicular type nelson, j. Immunohistochemical analysis of salivary gland canalicular adenoma. Please visit the project page for details or ask questions at wikipedia talk.
Canalicular adenoma is an unusual benign epithelial neoplasm of the minor salivary glands located primarily on the upper lip. Twentynine cases from the files of the afip are analyzed. This is a very rare benign neoplasm, that makes up about 1% of all salivary gland tumors, or about 4% of all benign salivary gland tumors. Canalicular adenoma is an uncommon benign salivary gland tumor almost exclusively occurring in intraoral glands. We report a case of canalicular adenoma in bilateral parotid glands, discuss histological characteristics, and. To our knowledge, this case represents the first reported case of a canalicular adenoma of the lacrimal gland. Canalicular adenoma is a benign, epithelial salivary gland neoplasm arranged in interconnecting cords of columnar cells. Background ca is an uncommon benign neoplasm that can develop in minor salivary gland duct tissues throughout the oral cavity. Canalicular adenoma is an uncommon salivary gland tumor arising almost exclusively from the minor salivary glands of the oral cavity. Histopathological examination of the specimen was significant for basal cell adenoma. The upper lip is the most common site followed by buccal mucosa. Historically considered a variant of basal cell adenoma bca, it wasnt until 1991 that the world health organisation who recognised this entity as being. Peak incidence of occurrence is sixth and seventh decade. In western countries, canalicular adenoma accounts for 0.
Distinct monomorphic adenoma with bilayered strands or ribbons of columnar cells with pure luminal ductal epithelial differentiation and loose, well vascularized stroma oral surg oral med oral pathol 1983. Synchronous bilateral multifocal canalicular adenoma. We represent basal cell adenoma of the parotid gland which was located on the deep lobe of the gland with unusual location the tumor was excised successfully without total parotidectomy. All structured data from the file and property namespaces is available under the creative commons cc0 license. Differential diagnosis of pleomorphic adenoma by immunohistochemical means volume 105 issue 12 toshiro nishimura, mitsuru furukawa, ei kawahara, atsuo miwa.
Many authors have included ca as a variant of basal. It appears as a slowgrowing node, less than 3 cm in diameter, painless, and nonulcerated. Canalicular adenoma definition of canalicular adenoma by. Canalicular adenomas are benign neoplasms with a unique predilection for the upper lip 80% of cases. Adequate preoperative imaging and differential diagnosis is paramount before proceeding with surgical intervention. Ca has a significant predilection for occurrence in the minor salivary glands, with most cases occurring in the upper lip, followed by the buccal mucosa and palate 15. This article is within the scope of wikiproject medicine, which recommends that medicinerelated articles follow the manual of style for medicinerelated articles and that biomedical information in any article use highquality medical sources. It is a rare entity, representing less than 1% of salivary gland tumors 2. Canalicular adenoma is a benign, epithelial salivary gland neoplasm arranged in. The canalicular adenoma is an uncommon, benign salivary gland neoplasm that usually occurs in or near the upper lip of elderly patients. Pleomorphic adenoma was the most common benign tumor 41% of all cases and 71% of benign tumors followed by monomorphic adenoma of the canalicular and basal cell subtypes 10% of all tumors and.
Among the intraoral minor salivary gland tumors it constitute 5. Canalicular adenoma ca is an uncommon, benign salivary gland tumor that was described by the world health organization classification in 1991. These tumors have undergone taxonomic drift, with many terms used to describe these tumors over the years table 1. There is a lack of a comprehensive immunohistochemical ihc analysis of canalicular adenoma canad, especially when combined with a description of the unique histologic features. To report a case of canalicular adenoma ca and discuss the use of immunohistochemistry to better address the diagnosis given some unusual characteristics in this patient. We report the case of an 84 year old male who had been complaining of a slow growing painless mass on the upper lip. Canalicular adenomas from five patients were examined by light and electron microscopy. Among the salivary gland neoplasms minor salivary gland neoplasms are often deceptive to the clinician and challenging to the pathologist because of their varied morphology and. Although basic pattern of the tumour is variable, individual cells are not pleomorphic. Canalicular adenoma is a benign neoplasm of the minor salivary glands.
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